pentobarbital will reduce the level or impact of diazepam buccal by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Use Warning/Keep an eye on. Sturdy or moderate CYP3A4 inducers may possibly boost price of diazepam elimination; therefore, efficacy of diazepam may very well be diminished.
pentobarbital will lower the extent or influence of itraconazole by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Small/Importance Unidentified.
CYP3A4 inducers may possibly boost the metabolism of clopidogrel to its Energetic metabolite. Keep track of clients for likely increase in antiplatelet effects when CYP3A4 inducers are utilised together with clopidogrel
Reserve concomitant prescribing of those drugs in clients for whom other cure selections are insufficient. Limit dosages and durations for the minimal needed. Observe closely for indications of respiratory despair and sedation.
pentobarbital will lessen the level or result of vinblastine by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Small/Importance Unfamiliar.
pentobarbital will lessen the level or influence of larotrectinib by affecting hepatic/intestinal enzyme CYP3A4 metabolism.
With therapeutic doses of TCAs, barbiturates raise metabolism and reduce blood concentrations of TCAs.
pentobarbital will minimize the extent or impact of avanafil by influencing hepatic/intestinal enzyme CYP3A4 metabolism. Use Warning/Check. For patients with ED, observe reaction meticulously because of probable for lowered usefulness.
Watch INR much more usually if coadministered with inducers of website these isoenzymes and adjust warfarin dose if desired.
pentobarbital will lessen the level or effect of dexamethasone by influencing hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Monitor.
pentobarbital will reduce the extent or impact of tamoxifen by influencing hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Keep an eye on.
buprenorphine subdermal implant and pentobarbital the two enhance sedation. Prevent or Use Alternate Drug. Restrict use to people for whom alternative therapy solutions are inadequate
Way too immediate administration may induce respiratory depression, laryngospasm, apnea, or vasodilation with fall in hypertension
pentobarbital will lower the extent or impact of nitrendipine by influencing hepatic/intestinal enzyme CYP3A4 metabolism. Small/Importance Not known.